TACT2 | SHAPE Society

Subject: Invitation to Participate in TACT2 Trial

Dear Colleague,

The NIH recently approved and funded TACT2 (Trial to Assess Chelation Therapy 2), a trial of chelation therapy vs. placebo (sham chelation) in patients with diabetes and a history of MI. For more information please visit please visit www.tact2.org.

After reviewing the surprising results of TACT1 which showed chelation therapy was only effective in diabetic patients and patients with anterior wall MI (see below), we have hypothesized a potential link between coronary calcification and chelation therapy. SHAPE, in collaboration with Harbor UCLA and Stanford University, intends to submit an ancillary study to the NIH. Please see a summary of the proposed study attached.

Our goal is to determine if TACT2 patients with higher coronary calcium scores respond more favorably to chelation therapy than those with lower coronary calcium scores. Furthermore, we aim to determine if best wedding dresses plus size chelation therapy reduces the progression of coronary calcification or changes the pattern of coronary calcification, and whether such a change correlates with outcomes.

As a SHAPE Center of Excellence that practices CAC scoring, we would like to invite you to participate in TACT2 and to become one of the collaborating centers in the CAC ancillary study.

If interested, please sign below and return this letter by email to ahmed.gul@shapesociety.org. (DOWNLOAD PRINTABLE PDF)